Hantzsch synthesis of bis(pyrido[2,3-d:6,5-d']dipyrimidines), bis(pyrimido[4,5-b]quinolines), and bis(benzo[4,5]imidazo[2,1-b]quinazolines) linked to pyrazole units as novel hybrid molecules

Abstract

Bis(1-phenylpyrazole-4-carboxaldehydes) were utilized as versatile precursors to novel series of bis(pyrido[2,3-d:6,5-d']dipyrimidines), bis(pyrimido[4,5-b]quinolines), and bis(benzo[4,5]imidazo[2,1-b]quinazolines) derivatives which are linked to pyrazole units.

Graphical Abstract

Keywords:

• Bis(benzo[4,5]imidazo[2,1-b]quinazolines)
• bis(pyrido[2,3-d:6,5-d']dipyrimidines)
• bis(pyrimido[4,5-b]quinolines)
• Hantzsch like reaction
• 6-aminouracil