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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 51, 2021 - Issue 14
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Articles

An efficient approach for the synthesis and antimicrobial evaluation of some new benzocoumarins and related compounds

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Pages 2175-2186 | Received 02 Jan 2021, Published online: 12 May 2021
 

Abstract

A convenient synthetic approach for pharmaceutically important benzocoumarin-based heterocyclic compounds has been studied. β-enaminonitrile has been used for the synthesis of a broad diversity of new benzocoumarins and related compounds over different reaction steps. Various synthetic approaches were used in this research for synthesis of heterocyclic systems such as acid-catalyzed hydrolysis, decarboxylation, deamination, ring opening and ring closure. The molecular structures of the newly synthesized derivatives were established by elemental analyses and spectral data (IR, 1H-NMR, and 13C-NMR). Some of the newly synthesized compounds were explored for their antimicrobial activities.

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