An efficient approach to 3-thioether-functionalized 2,3-dihydrobenzofurans via a metal-free intramolecular radical cyclization/thiolation cascade reaction

Abstract

A diverse series of 3-thioether-functionalized 2,3-dihydrobenzofurans were prepared by an intramolecular radical cyclization/thiolation cascade reaction of alkenyl-tethered arenediazonium salts with thiophenols under transition-metal-free conditions. The mild and practical reaction conditions tolerated various functional groups and afforded the corresponding 2,3-dihydrobenzofurans in moderate to good yields.

Graphical Abstract

Keywords:

• Cyclization
• dihydrobenzofurans
• diazonium salts
• phenthiols

Acknowledgements

Our present work was financially supported by the Chemical Engineering & Technology of Zhejiang Province First-Class Discipline (Taizhou University).

Additional information

Funding

The present work was financially supported by the Chemical Engineering & Technology of Zhejiang Province First-Class Discipline (Taizhou University).