Recent developments in the synthesis of N-aryl sulfonamides

Abstract

The construction of N-aryl sulfonamides is usually an important reaction in organic synthesis because these compounds are privileged in the structure of many natural products and pharmaceutical molecules. Also, N-aryl sulfonamides are well-known due to their antibacterial, antitumor, and anti-HIV biological activities. Therefore, research on the laboratory synthesis of N-aryl sulfonamides is an important challenge in organic synthesis. In this review, we discussed on methods reported up to now for the synthesis of N-aryl sulfonamides with the goal of stimulating further progresses in this field. We believe that this review will open up a new road for the preparation of pharmaceutically and biologically active sulfonamides.

Graphical Abstract

Keywords:

• Biological activities
• laboratory synthesis
• N-arylsulfonamides
• organic synthesis
• pharmaceutical chemistry

Additional information

Funding

This work was supported by Zhejiang Shuren University Basic Scientific Research Special Funds [2020XZ011].