Neat synthesis of c-fused pyrroles and its application to macrolactamization

Abstract

The current study describes an efficient environmental benign synthetic route of N-aryl substituted c-fused pyrrole derivatives via neat approach. It also provides base-mediated intramolecular macrolactamization using amine ester amidation reaction and leads to fused diazocine-6(5H)-one with effective yields.

Graphical Abstract

Keywords:

• Aza-Michael addition
• c-fused pyrrole
• diazocine-6(5H)-one
• macrolactamization
• neat reaction

Acknowledgments

The authors thank the Department of Science & Technology And Biotechnology under the Government of West Bengal [1208 (sanc.)/ST/P/S&T/15G-44/2017] for providing the financial support.

Disclosure statement

No potential conflict of interest was reported by the author(s).