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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 51, 2021 - Issue 16
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Synthetic Communications Reviews

Dicarbonyl compounds in O-heterocycle synthesis

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Pages 2423-2444 | Received 04 Apr 2021, Published online: 24 Jun 2021
 

Abstract

Heterocycles have maintained their popularity among researchers in all these years due to their important activities in pharmaceuticals. Several reports on the synthesis of heterocycles including coumarin, pyran, oxazole, and thiazole for drugs have been published. The O-heterocycles are present in drugs like rantidine, doxepin, and paclitaxel. Various diketones such as β-diketones, 1,3-diketones, 1,4-diketones and dicarbonyl compounds play a vital role in synthetic organic chemistry and are used in the synthesis of core heterocyclic compounds. This review article covers the syntheses of O-heterocycles from dicarbonyl compounds.

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