Abstract
A new synthetic route leading to functionalized 1H-1,2,3-triazole-4-carbonitriles has been developed. A set of 1-aryl-5-methyl-1H-1,2,3-triazole-4-carbonitriles was obtained in high yields from readily available starting 1H-1,2,3-triazole-4-carboxylic acids via several synthetic protocols. Synthesized 1H-1,2,3-triazole-4-carbonitriles were examined as promising precursors in the simple and efficient method for the preparation of the 2-triazol-4-yl-thieno[2,3-d]pyrimidines. Such an approach allows creating broad combinatorial libraries for anticancer drug discovery.
Graphical Abstract
Acknowledgements
The authors thank Dr Evgeny Goreshnik (Department of Inorganic Chemistry and Technology, Jozef Stefan Institute) and Dr Yuriy Slyvka (Department of Inorganic Chemistry, Ivan Franko National University of Lviv) for X-ray crystallographic analysis.