Abstract
A protocol has been devised for the synthesis of 3-substituted 5-amino-1,2,4-thiadiazoles utilizing isothiocyanates, amidoximes and water as an eco-friendly solvent. The strategy involves consecutive C−N and S−N bonds formation in a one-pot reaction under catalyst-free conditions. Operational simplicity, low cost, broad substrate scope and readily available starting materials are the main features of this protocol.
Graphical Abstract
![](/cms/asset/3e502d88-e2ab-4a39-9b8b-36a442caaa19/lsyc_a_1986840_uf0001_c.jpg)
Acknowledgments
We are thankful to the NMR facility, Institute of Excellence, University of Mysore, Manasagangotri, Mysore, India for spectral data.