Microwave-assisted multicomponent reaction: An efficient synthesis of indolyl substituted and spiroxindole pyrido[2,3-d]pyrimidine derivatives

Abstract

An efficient and catalyst-free protocol for the synthesis of a series of indole substituted or spiroxindole-consisted dihydropyrido[2,3-d]pyrimidine derivatives by one-pot three-component reaction of 2,6-diaminopyrimidin-4-one, various aryl aldehydes or isatins, and 3-cyanoacetyl indoles under microwave irradiation was investigated. The advantages of this methodology include high yields of products, short reaction time, easy work-up procedure and broad substrate scope.

Graphical Abstract

Keywords:

• Dihydropyrido[2,3-d]pyrimidine
• indole
• microwave
• multi-component reaction

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was partially supported by the Natural Science Foundation of Jiangsu Province (BK20201017), the Xuzhou Science and Technology Project (KC19042 and KC20073), and Innovation and Entrepreneurship Training Program for Jiangsu College Students (202154).