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Abstract
Transition metal-free approaches for oxidative functionalization reactions have gained considerable importance over the past few decades. The recent updates on the use of TBAI (tetrabutylammoniumiodide) and TBHP (tert-butylhydroperoxide) as an efficient catalytic system for oxidative functionalization reactions on Csp3, Csp2, and Csp carbon have been described. The TBAI/TBHP synergistic combination proved to be a versatile catalytic condition for carrying out various oxidative transformations. Several reviews covering this topic have already been published. However, no comprehensive review covering the oxidative functionalization reactions on different hybridized carbon atoms was reported. In this review, we will cover oxidative reactions developed over the recent years promoted by TBAI/TBHP catalytic system. The mechanistic insights have described TBAI as the radical initiator which can lead to the generation of tert-butylhydroperioxideradical or itself gets oxidized to (hypo)iodite by TBHP.
Graphical Abstract
Acknowledgments
F.A.S. thanks UGC, New Delhi for the award of the Dr. D. S. Kothari Post-Doctoral Fellowship. R.S. thanks DST-SERB, New Delhi for the award of a postdoctoral research fellowship (file no. PDF/2017/000232).