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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 52, 2022 - Issue 2
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Articles

Total synthesis of Berkeleylactone F

Anantha Reddy Vakitia Medicinal Chemistry Division 28A, IDA, GVK Biosciences Private Limited, Hyderabad, India;b Department of Chemistry, Koneru Lakshmaiah Education Foundation, Guntur, IndiaView further author information
,
Krishna Reddy Vallurua Medicinal Chemistry Division 28A, IDA, GVK Biosciences Private Limited, Hyderabad, IndiaView further author information
,
S. Naresh Vermab Department of Chemistry, Koneru Lakshmaiah Education Foundation, Guntur, IndiaView further author information
,
Tasqeeruddin Syedc Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi ArabiaView further author information
,
Gattu Sridhard Department of Chemistry, Kakatiya Institute of Technology and Science, Warangal, IndiaView further author information
&
J. V. Shanmukha Kumarb Department of Chemistry, Koneru Lakshmaiah Education Foundation, Guntur, IndiaCorrespondence[email protected]
View further author information
Pages 205-211 | Received 22 Jul 2021, Published online: 07 Dec 2021
 
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Abstract

An efficient total synthesis of Berkeleylactone F has been synthesized from the known starting materials. The key steps involved in the synthesis are Wittig reaction, epoxide ring opening with 1, 3-dithiane and Yamaguchi macrolactonization.

Graphical Abstract

Acknowledgments

The authors are thankful to Department of Chemistry, Koneru Lakshmaiah Education Foundation, Guntur and GVK Biosciences, Pvt. Ltd for providing facilities to carry out our research work.

Additional information

Funding

The authors are grateful to the Deanship of Scientific Research, King Khalid University for the financial support [Grant No. RGP. 1/185/42].

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