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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 52, 2022 - Issue 2
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Articles

Ligand-free Zn-catalyzed double carbonylation of aryl iodides with secondary amines: A simple and efficient approach to access α-ketoamides

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Pages 212-217 | Received 10 Aug 2021, Published online: 07 Dec 2021
 

Abstract

Herein, we report a Zinc catalyzed double carbonylation of aryl iodides with secondary amines under CO pressure for the synthesis of α-ketoamides in good to excellent yields. This methodology provides a simple and economic approach to derivatize useful α-ketoamides.

Graphical Abstract

Acknowledgements

The authors thank Aragen Life Sciences (Formerly known as GVK Biosciences) for providing the facilities in which this research was performed. In addition, we would like to thank Dr Somesh, Dr Satyanarayana Yennam and Dr Gajendra for their continuous support.

Supplementary data

Experimental details, characterization and copies of 1H and 13C NMR products can be found online at http://dx.doi.org/

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