Synthesis, characterization, and antifungal activity of novel chromene oxadiazole based dithiocarbamates

Abstract

A series of novel conjugated chromene oxadiazole-based dithiocarbamate (5a–i) derivatives have been synthesized from oxadiazole (4a–c) intermediates with carbon disulfide. The structures of all the newly synthesized compounds were established by IR, NMR, and Mass spectral analysis. The synthesized derivatives were screened for their antifungal activity against Aspergillus niger fungal strain and the results showed that some of the derivatives were found to exhibit good antifungal activity.

Graphical Abstract

Keywords:

• Antifungal activity
• chromene
• dithiocarbamates
• oxadiazole

Acknowledgments

Konda sincerely thanked AP-NL projects, India, for providing Senior Research fellowship and Head Department of Chemistry and CFRD, Osmania University, Hyderabad, India for providing laboratory facilities and spectral data.