Nanocatalyzed synthetic approach for quinazoline and quinazolinone derivatives: A review (2015–present)

Abstract

Quinazolines and their derivative are among the most significant heterocyclic compounds due to their several chemical reactivities and vital range of biological activity. Although a tremendous number of research papers are dedicated to synthesizing quinazolines and their derivatives using reaction conditions like expensive catalysts, multistep reactions, high temperature, use of the base and toxic solvents. But moving toward a greener approach, nanocatalysts have emerged as potential candidates owing to high surface area and more exposed active sites for reactants which enhances the selectivity and reduces the quantity of catalyst requirement. The synthesis of quinazoline derivatives is mainly limited to primary screening using eco-friendly nanocatalysts. This review provides the biological importance of quinazoline and its derivatives and enlists the various nanocatalysts (2015–present) involved in the synthesis of quinazolines and their derivative with emphasis on synthetic strategies and catalytic performances. This review will provide an idea for the rational designing of eco-friendly, novel and efficient nanocatalysts.

Graphical Abstract

Keywords:

• Quinazolines
• quinazolinones derivatives
• anti-tumor
• nanocatalyst

Acknowledgements

The authors Parveen Kumar, Vijesh Tomar, Raj Kumar Joshi, and Meena Nemiwal are thankful to MNIT Jaipur for providing support to carry out this work.