A new facile synthesis of (2S,5S)-5-hydroxypipecolic acid hydrochloride

Abstract

A simple and efficient synthesis of (2S,5S)-5-Hydroxypipecolic acid hydrochloride is reported. The key features of the synthesis involve the asymmetric reduction of ketone using (S)-CBS oxazaborolidine and the use of commercially available methyl pyroglutamate as a starting material. 

Graphical Abstract

Keywords:

• HCl salt of 5-hydroxypipecolic acid
• methyl pyroglutamate
• piperidine
• (S)-CBS-oxazaborolidine

Acknowledgments

The authors would like to thank Dr. Reddy’s Laboratory, Hyderabad for their support to carry out this work.

Disclosure statement

The authors declare no conflicts of interest.