Microwave-assisted intramolecular palladium-mediated cyclizations of o-iodobenzophenones for methoxy fluoren-9-ones

Abstract

Microwave (MW) irradiation is an effective tool in organic reactions that required long reaction times under thermal conditions. Herein substituted 2-iodobenzophenones were transformed into substituted fluoren-9-ones via cesium carbonate and bis(triphenylphosphine) palladium(II) chloride with 56–92% yields within 30–45 min under microwave irradiations. A remarkable decrease in the reaction time with high yield products was observed. The isolated products have been emphasize on the basis of (¹H/¹³CNMR) and correlations spectra.

Graphical Abstract

Keywords:

• C-C bond formation
• fluoren-9-ones
• halobenzophenones
• hipposudoric acid
• microwave
• palladium arylations

Acknowledgements

I am thankful to the Bioorganic Chemistry Institute, Hohenheim University, Stuttgart, and Gottingen University, Germany for supplying me with laboratory possibilities for the achievement of this article.

Disclosure statement

This article holds no conflict of interest and is not funded through any source.