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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 52, 2022 - Issue 17
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Articles

Photocatalyzed difluoroalkylation of pyridine N-oxides

, , , , , & ORCID Icon show all
Pages 1727-1741 | Received 20 May 2022, Published online: 19 Aug 2022
 

Abstract

A photoredox catalytic strategy has been developed for the regioselective C2-, or C4-difluoroalkylation of pyridine N-oxides under mild conditions. This method provides an efficient protocol for the incorporation of electrophilic difluoroacetate radical (CF2CO2Et) into pyridine skeletons, based on the strategy of nitrogen-atom activation on electron-deficient pyridine moieties.

Graphical Abstract

Acknowledgments

The authors thank the Laboratory of Micro-structures of Shanghai University for structure analysis.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was financially supported by the National Natural Science Foundation of China (Nos. 21572128 and 21672139).

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