Abstract
A photoredox catalytic strategy has been developed for the regioselective C2-, or C4-difluoroalkylation of pyridine N-oxides under mild conditions. This method provides an efficient protocol for the incorporation of electrophilic difluoroacetate radical (CF2CO2Et) into pyridine skeletons, based on the strategy of nitrogen-atom activation on electron-deficient pyridine moieties.
Graphical Abstract
![](/cms/asset/bdb989c1-f924-4646-aec6-828c1d5b6a12/lsyc_a_2112057_uf0001_c.jpg)
Acknowledgments
The authors thank the Laboratory of Micro-structures of Shanghai University for structure analysis.
Disclosure statement
No potential conflict of interest was reported by the author(s).