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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 52, 2022 - Issue 18
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Articles

Acid-promoted synthesis of pyrazolo[4,3-c]quinoline derivatives by employing pyrazole-arylamines and β-keto esters via cleavage of C–C bonds

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Pages 1796-1804 | Received 30 Jun 2022, Published online: 24 Aug 2022
 

Abstract

An approach for the synthesis of pyrazolo[4,3-c]quinoline derivatives has been developed by the combination of pyrazole-arylamines and β-keto esters via cleavage of C–C bonds. The strategy shows good tolerance and compatibility with a wide range of functional groups. Moreover, this method features simple conditions, generates a series of alkyl substituted pyrazolo[4,3-c]quinoline, and provides the desired products in moderate to good yields.

Graphical Abstract

Acknowledgments

Dedicated to our distinguished friend Prof. Baohua Chen on the occasion of his 60th birthday.

Additional information

Funding

We greatly acknowledge financial support from Ningxia Natural Science Foundation Program [2021AAC03269 and 2022AAC03448] and Ningxia Key Research and Development Program [2022CMG02007].

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