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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 52, 2022 - Issue 18
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Synthetic Communications Reviews

Strategies toward the total synthesis of pretubulysin, its fragments and analogues

Nosheen Iqbala Department of Chemistry, Government College University Faisalabad, Faisalabad, Pakistan
,
Ameer Fawad Zahoora Department of Chemistry, Government College University Faisalabad, Faisalabad, PakistanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2127-8848
ORCID Icon,
Matloob Ahmada Department of Chemistry, Government College University Faisalabad, Faisalabad, PakistanORCID Iconhttps://orcid.org/0000-0003-1302-8056
ORCID Icon,
Freeha Hafeezb Department of Chemistry, Riphah International University Islamabad, Faisalabad, Pakistan
,
Muhammad Sulemanb Department of Chemistry, Riphah International University Islamabad, Faisalabad, Pakistan
,
Samra Barkaatb Department of Chemistry, Riphah International University Islamabad, Faisalabad, Pakistan
,
Rabia Akhtara Department of Chemistry, Government College University Faisalabad, Faisalabad, Pakistan
&
Raheel Ahmada Department of Chemistry, Government College University Faisalabad, Faisalabad, Pakistan
 show all
Pages 1769-1787 | Received 13 May 2022, Published online: 01 Sep 2022
 
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Abstract

Pretubulysin, a biosynthetic precursor of tubulysins, exhibits potent cytotoxicity in subnanomolar range toward several cancer cell lines. This natural product (extracted from myxobacterial strains) along with its derivatives plays an important role in the development of a variety of antitumor drugs. In this review, natural and synthetic pretubulysins, as well as their synthetic analogues have been discussed in detail.

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