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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 52, 2022 - Issue 24
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Articles

An easy and regioselective synthesis of new functionalized isoxazoline derivatives via a 1,3-dipolar cycloaddition reaction

Chaima Messaoudia Laboratoire de Synthèse Organique Sélective et Hétérocyclique-Evaluation de l’activité biologique, LR17ES01, Université de Tunis El Manar, Faculté des Sciences de Tunis, Tunis, Tunisie;b Laboratoire de Physico-Chimie des Matériaux et des Electrolytes pour l’Energie (PCM2E), EA 6299, Avenue Monge, Faculté des Sciences, Université de Tours, Parc de Grandmont, Tours, France
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Momtez Jmaïa Laboratoire de Synthèse Organique Sélective et Hétérocyclique-Evaluation de l’activité biologique, LR17ES01, Université de Tunis El Manar, Faculté des Sciences de Tunis, Tunis, Tunisie
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Badr Jismyb Laboratoire de Physico-Chimie des Matériaux et des Electrolytes pour l’Energie (PCM2E), EA 6299, Avenue Monge, Faculté des Sciences, Université de Tours, Parc de Grandmont, Tours, France
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Mohamed Abarbrib Laboratoire de Physico-Chimie des Matériaux et des Electrolytes pour l’Energie (PCM2E), EA 6299, Avenue Monge, Faculté des Sciences, Université de Tours, Parc de Grandmont, Tours, FranceCorrespondence[email protected]
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Hedi M’rabeta Laboratoire de Synthèse Organique Sélective et Hétérocyclique-Evaluation de l’activité biologique, LR17ES01, Université de Tunis El Manar, Faculté des Sciences de Tunis, Tunis, Tunisie
Pages 2291-2300 | Received 27 Sep 2022, Published online: 11 Nov 2022
 
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Abstract

An efficient and original synthesis of various aminophosphonate-containing isoxazoline derivatives is reported. A library of variously substituted compounds was readily synthesized via a 1,3-dipolar cycloaddition reaction of β-ethoxycarbonyl N-methylphosphonated allylic amines used as dipolarophiles with chloroximes under mild conditions.

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