Facile synthesis of indolizino[8,7-b]indole and pyrido[1,2-a:3,4-b’]diindole derivatives based on domino reactions of 1-aroyl-3,4-dihydro-β-carbolines

Abstract

A convenient approach to the synthesis of 1-aroyl-3,4-dihydro-β-carbolines via Pictet–Spengler reaction has been developed. A variety of reagents, such as unsaturated aldehydes, ketones, maleic anhydride in the construction of functionally diverse indolizino[8,7-b]indole, and pyrido[1,2-a:3,4-b’]diindole derivatives has been used. The developed method is a simple and convenient procedure giving medium and excellent yields, showing a wide functional group tolerance.

Graphical Abstract

Keywords:

• Domino reaction
• electron-deficient alkenes
• Pictet–Spengler

Acknowledgments

The X-ray studies were fulfilled using a Stoe StadiVari Pilatus-100 K diffractometer purchased by MSU Development Program.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This article has been supported by the RUDN University Strategic Academic Leadership Program.