Abstract
Chalcone derivatives are frequently found in bioactive compounds, natural products, and pharmaceuticals. In this study, we developed a KOtBu/DMF catalytic system to efficiently synthesize chalcone derivatives by isomerizing propargylic alcohols bearing aryl substituents at the 1- and 3-positions. Mechanistic investigations confirmed that a 1,3-hydride shift was the key process for the successful reaction. Our method does not involve the use of transition metals and possesses economic and environmental benefits.
Graphical Abstract
Disclosure statement
No potential conflict of interest was reported by the author(s).