Abstract
A facile and rapid synthesis of a family of new hybrid system 1,5-disusbtituted 1H-tetrazol-5yl 4,5-dihydro [1,2,3]triazolo[1,5-a]pyrazin-6-ones in moderate yields is described. Compounds were synthetized by a high-order multicomponent reaction (MCR) to give N-acylated 1,5-disubstituted tetrazoles followed, without chromatographic purification, by an SN2/intramolecular [3 + 2] cycloaddition sequence. The target molecules could be useful in drug discovery processes because they contain two very important pharmacophoric moieties: 1,5-disubstituted tetrazole and 1,2,3- triazole.
Graphical Abstract
Acknowledgments
C.M. A-M. (756225) and G. S-G. (772950) acknowledges the support of CONACYT through a graduate scholarship. All authors are grateful for financial support from Programa para el Desarrollo Profesional Docente, para el Tipo Superior (PRODEP PTC-404) and CIC-UMSNH (14766), as well as Ph.D student Josue Valentin Escalera for English support.
Disclosure statement
No potential conflict of interest was reported by the author(s).