Abstract
Some pyrazole-based heterocycles, such as pyrrolone, pyridazinone, and imidazole derivatives were synthesized utilizing the pyrazolyl-2(3H)-furanone derivative 3, which was obtained in a good yield via Perkin condensation of 5-chloro-4-formyl-3-methyl-1-phenylpyrazole with 3-(4-methylbenzoyl)propionic acid in the presence of cyclo-dehydrating agent (sodium acetate and acetic anhydride). Also, the acid hydrazide obtained was reacted with some carbonyl reagents like acetic anhydride, benzoyl chloride, 4-chlorobenzaldehyde, and 1,3-diphenyl-4-formylpyrazole, aiming to achieve new pyrrolone derivatives. The antioxidant activity screening of some synthesized compounds demonstrated that pyridazinone and N-phenylhydrazide derivatives showed the most exceptional potencies.
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Acknowledgments
We greatly thank Dr. M. A. Ghareeb, Theodor Bilharz Research Institute, Giza, Egypt, for making the antioxidant activity evaluation.
Author contributions
All authors have equally contributed to the work.
Disclosure statement
No potential conflict of interest was reported by the author(s).