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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 53, 2023 - Issue 13
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Articles

Theophylline Hydrogen Sulfate: A green and efficient catalyst for synthesis of 3,3-bis(1H-indol-3-yl)indolin-2-one derivatives

Ganesh B. Punda Department of Chemistry, Dr. Rafiq Zakariya College For Women, Aurangabad, IndiaORCID Iconhttps://orcid.org/0000-0003-1560-6171
ORCID Icon,
Diksha B. Wahulb Department of Chemistry, MSS’S Arts, Science and Commerce College Ambad, Ambad, India
,
Tejshri R. Deshmukhc Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, IndiaORCID Iconhttps://orcid.org/0000-0002-1818-0316
ORCID Icon,
Sambhaji T. Dhumald Department of Chemistry, Ramkrishna Paramhansa Mahavidyalaya, Osmanabad, IndiaORCID Iconhttps://orcid.org/0000-0003-3018-6179
ORCID Icon,
Krishna R. Mandavee Department of Chemistry, Maulana Azad College of Arts Science and Commerce, Aurangabad, India
,
Sujeet A. Gawaref Department of Chemistry, Institute of Chemical Technology-Indian Oil Odisha, IIT Kharagpur Extension Centre, Bhubaneswar, India
,
Mazahar Farooquie Department of Chemistry, Maulana Azad College of Arts Science and Commerce, Aurangabad, India
,
Bhagwansing S. Dobhalg Department of Chemistry, Badrinarayan Barwale Mahavidyalaya, Jalna, IndiaORCID Iconhttps://orcid.org/0000-0002-9469-3869
ORCID Icon &
Madhav J. Hebadeg Department of Chemistry, Badrinarayan Barwale Mahavidyalaya, Jalna, IndiaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0008-8834
ORCID Icon show all
Pages 1008-1019 | Received 21 Jan 2023, Published online: 07 May 2023
 
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Abstract

A new green protocol for the synthesis of 3,3-bis(1H-indol-3-yl)indolin-2-one derivatives by reacting isatin with indole in the presence of Theophylline Hydrogen Sulfate as a new solid acid, a highly effective and reusable catalyst. This reaction was carried out by using aqueous ethanol as a solvent system at room temperature with constant stirring. A highly effective solid acid catalyst, short reaction time, better to excellent yields of the products, safe and environmentally benign reaction conditions are some of the benefits of the present synthetic method.

GRAPHICAL ABSTRACT

Acknowledgments

The author G.B.P. is very much thankful to the Council for Scientific and Industrial Research (CSIR), New Delhi, for the award senior research fellowship. File No. 08/613(0005)/2018-EMR-I

Disclosure statement

The author declare no conflict of interest.

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