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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 53, 2023 - Issue 16
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Articles

An alternate synthesis of sporiolide B from (R)-glyceraldehyde

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Pages 1333-1338 | Received 10 Jan 2023, Published online: 04 Jun 2023
 

Abstract

In this article, a novel synthetic route was described for the total synthesis of Sporiolide B from inexpensive and commercially available starting materials by a concise fourteen-step sequence in 6.50% overall yield. This convergent synthesis utilizes Grignard reaction, Asymmetric dihydroxylation, Yamaguchi macrolactonization and ring closing metathesis as the key steps.

Graphical Abstract

Acknowledgments

The authors are thankful to Krishna University, Rudravaram, Machilipatnam for constant encouragement during this research program and thanks to GVK Biosciences Private Limited for providing basic research facility.

Additional information

Funding

The authors are also grateful to the Deanship of Scientific Research, King Khalid University for the financial support [Grant No. RGP. 1/218/43].

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