Abstract
In this article, a novel synthetic route was described for the total synthesis of Sporiolide B from inexpensive and commercially available starting materials by a concise fourteen-step sequence in 6.50% overall yield. This convergent synthesis utilizes Grignard reaction, Asymmetric dihydroxylation, Yamaguchi macrolactonization and ring closing metathesis as the key steps.
Graphical Abstract
![](/cms/asset/a4d2b475-5640-4503-9835-f653bd8ff684/lsyc_a_2220443_uf0001_b.jpg)
Acknowledgments
The authors are thankful to Krishna University, Rudravaram, Machilipatnam for constant encouragement during this research program and thanks to GVK Biosciences Private Limited for providing basic research facility.