An efficient synthesis of 3-fluoro chromones from the tandem cyclization of enaminones by using N-Fluoro benzenesulfonimide

Abstract

An efficient method of synthesizing the various 3-Fluorochromones from enamino ketones by using N-Fluoro benzenesulfonimide (NFSI) is described. The key step in the synthesis involves tandem cyclization and fluorination to form 3-fluorochromones in good yields. The significant features of this method include simple operational procedures, high purity of the product and cost reducing. This reaction achieved good to excellent yields (51–92%) under ambient conditions with significantly faster rate. The products obtained were confirmed by ¹H, ¹³C NMR and mass spectroscopy techniques.

Graphical Abstract

Keywords:

• Enaminones
• fluorination
• fluoro chromones
• N-fluoro benzenesulfonimide (NFSI)
• synthesis
• word

Acknowledgements

The authors thank Aragen Life Sciences (Formerly known as GVK Biosciences) for providing the facilities in which this research was performed.