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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 53, 2023 - Issue 19
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Articles

Catalyst free, one-pot green synthesis of 2-aryl-2-oxazoline derivatives from aryl nitrile using ionic liquid

Shrikant M. GhodseDepartment of Pharmaceutical Chemistry, Prin. K. M. Kundnani College of Pharmacy, Affiliated to University of Mumbai, Mumbai, IndiaCorrespondence[email protected]
&
Pallavi D. BardeDepartment of Pharmaceutical Chemistry, Prin. K. M. Kundnani College of Pharmacy, Affiliated to University of Mumbai, Mumbai, India
Pages 1616-1622 | Received 25 May 2023, Published online: 24 Jul 2023
 
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Abstract

A catalyst free methodology for the synthesis of 2-aryl-2-oxazoline derivatives under conventional heating using ionic liquid 1-butyl-3-methylimidazolium bromide ([bmim]Br) as neutral reaction media is described. Various aryl nitriles condensed with 2-aminoethanol was studied to afford corresponding products in good to excellent yields in short reaction time. This method is operationally simple, green, and easy workup procedure.

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