Abstract
Thiouracil and uracil derivatives are among the bioactive molecules used in the treatment of many diseases, such as 6-propylthiouracil and 5-fluorouracil. A new synthesis method of 6-methylthiouracil and 6-methyluracil was developed in this study. Various 6-methylthiouracil and 6-methyluracil derivatives were obtained by reacting 2,2,6-trimethyl-4H-1,3-dioxin-4-one with thiourea and urea compounds in the presence of Yb(TFA)3 according to this new method. Optimization of this new method was performed. The structures of 6-methylthiouracil and 6-methyluracil derivatives were characterized.
Graphical abstract
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Supporting Information summary
Supporting Information is included in full experimental detail (1H-NMR, 13 C-NMR spectra, LC-MS, IR). This material can be found via this article’s webpage’s “Supplementary Content” section.