Recent advances in meglumine catalyzed organic synthesis: A comprehensive review

Abstract

Meglumine, an amino sugar alcohol compound, has recently emerged as a promising catalyst in various organic transformations due to its unique properties. This review provides a comprehensive overview of the applications of meglumine catalyst in organic synthesis, highlighting their efficiency, versatility, and mechanistic insights. Key examples of reactions catalyzed by meglumine, including aldol condensation, Michael addition, Mannich reaction, and other one-pot multicomponent condensation reaction are discussed along with mechanistic pathways and synthetic strategies. Additionally, recent advancements and future perspectives in the field are explored.

GRAPHICAL ABSTRACT

Keywords:

• Bio-degradable
• catalysis
• green synthesis
• meglumine
• multicomponent reactions (MCRs)
• one-pot synthesis
• recycled
• reusable

Acknowledgement

The authors are thankful to the department of chemistry, Monark University, Hasmukh Goswami College of Engineering AT, Vahelal - Dahegam road, Naroda, Ahmedabad, Gujarat, for providing the necessary facilities.

Disclosure statement

The authors declare that they have no competing interests.

Additional information

Notes on contributors

Dharti R. Bhandari

Dharti R. Bhandari has obtained her B.Sc. degree in Chemistry from the Veer Narmad South Gujarat University, Surat (India), in 2017 and her M.Sc. degree in Organic Chemistry involving a dissertation entitled “Synthesis of heterocyclic compounds and their biological activity” from the a Uka tarsadiya University (Surat) in 2019. At present, she is pursuing Ph.D. under guidance of Dr. Jinal A. Gajjar at Monark University. Her current research work involves “Synthesis, Characterization of Nitrogen & Sulphur Based heterocyclic compounds and their Antimicrobial Activity”.

Urvi J. Khengar

Urvi J. Khengar has obtained her B.Sc. degree in Chemistry from the Veer Narmad South Gujarat University, Surat (India), in 2015 and her M.Sc. degree in Organic Chemistry involving a dissertation entitled “Synthesis of heterocyclic compounds and their biological activity” from the same University in 2017. At present, she is pursuing Ph.D. under guidance of Dr. Jinal A. Gajjar at Monark University. Her current research work involves “One pot synthesis of heterocyclic compounds and their application”.

Rajesh H. Vekariya

Dr. Rajesh H. Vekariya obtained his B.Sc. Degree in Chemistry in 2010 and his M.Sc. Degree in organic chemistry in 2012 both from the Gujarat University, Ahmedabad (India). He had worked as research associate at Oxygen Bio Research, Ahmedabad, Gujarat during the period of June 2012 to October 2012. He received his Ph.D. in Organic Chemistry (2017) from the Chemistry Department, Gujarat University, Ahmedabad (India) under the supervision of Dr. Hitesh D. Patel. His study focuses on the synthesis of organic intermediates using green chemistry and their use in the production of physiologically active molecules. He also works on the synthesis of industrially significant organic intermediates using a step-down technique, as well as the creation of more environmentally friendly and cost-effective ways. He is actively working on the creation of different liquid crystal materials and nanocatalysts. He has around seven years of R&D expertise in pure synthetic organic and bio-organic chemistry. He has been working as an Assistant Manager at Gujarat Fluorochemicals Limited in Gujarat, India, since 2021.

Jinal A. Gajjar

Dr. Jinal A. Gajjar has obtained her B.Sc. degree in Chemistry from the Gujarat University, Ahmedabad (India), in 2013 and her M.Sc. degree in from the same University in 2015. She has done M. Phil. Degree in organic chemistry involving a dissertation entitled “Synthesis of supramolecular chemistry and it’s application” under the guidance of Prof. Hitesh D. Patel at the Chemistry Department of the Gujarat University, Ahmedabad in 2017. She received her Ph.D. in Organic Chemistry (2021) from the Chemistry Department, Gujarat University, Ahmedabad (India) under the supervision of Dr. Hitesh Parekh. Her study focuses on the synthesis of different Resorcin[4]arene derivatives and their applications. At present, she has been working an Assistant professor at chemistry department, jeel goswami college of science and research, Monark University, Vahelal – Dahegam Rd, Naroda, Ahmedabad, Gujarat, India, since 2022. Her current research work involves synthesis of heterocyclic compounds by green chemistry methodology and their applications in various field such as design of metal-organic frameworks, biological, and catalysis. She also works on the synthesis of different supramolecular moiety and their different applications.