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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 41, 2011 - Issue 5
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Original Articles

Novel and Efficient Synthesis of tert-Butyl-2-(4-(2-aminoethyl)phenylthio)-2-methylpropanoate, a Key Intermediate in the Synthesis of Ureido Thioisobutyric Acid

Jigar Desai Medicinal Chemistry Division, Zydus Research Centre, Ahmedabad, Gujarat, IndiaCorrespondence[email protected]
,
Anil Argade Medicinal Chemistry Division, Zydus Research Centre, Ahmedabad, Gujarat, India
,
Sanjay Gite Medicinal Chemistry Division, Zydus Research Centre, Ahmedabad, Gujarat, India
,
Kiran Shah Medicinal Chemistry Division, Zydus Research Centre, Ahmedabad, Gujarat, India
,
Laxmikant Pavase Medicinal Chemistry Division, Zydus Research Centre, Ahmedabad, Gujarat, India
,
Pravin Thombare Medicinal Chemistry Division, Zydus Research Centre, Ahmedabad, Gujarat, India
&
Pankaj Patel Medicinal Chemistry Division, Zydus Research Centre, Ahmedabad, Gujarat, India
 show all
Pages 748-753 | Received 05 Aug 2009, Published online: 31 Jan 2011
 
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Abstract

A convenient and cost-effective synthesis of pharmacologically important tert-butyl-2-(4-2-aminoethyl)phenylthio)-2-methylpropanoate from commercially available 2-2-phenyl-1-ethanol is described.

ACKNOWLEDGMENT

The authors are thankful to the management of Cadila Healthcare Limited for the scientific support.

Notes

ZRC Communication No. 239.

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