Versatile Synthesis of Fused Tricyclic 1,2,4-Triazole Derivatives

Abstract

The synthesis of a small series of fused tricyclic 1,2,4-triazoles is described. The key reaction is an intramolecular two-stage, one-pot reduction/cyclization sequence of a nitropyridine/oxadiazole substrate to give the key tricyclic triazole. Further standard transformations convert this template into a series of final target compounds.

Keywords:

• Fused tricyclic ring system
• intramolecular reduction cyclization
• Suzuki reaction
• 1,2,4-triazole
• vicarious nucleophilic substitution