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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 21, 1991 - Issue 22
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Original Articles

Stereoselective Addition of Methyl Acrylate to α-Amino Aldehydes

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Pages 2269-2274 | Received 19 Jun 1991, Published online: 23 Sep 2006
 

Abstract

Variously N-protected α-aminoaldehydes exhibit reasonable diastereoselectivity in the Baylis-Hillman coupling1 with methyl acrylate to provide either primarily syn or anti α-methylene-β-hydroxy-γ-amino esters.

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