An Efficient Synthesis of Diethyl 1-Aminoalkylphosphonate Hydrochlorides via the Intermediate Diethyl 1-Azidoalkylphosphonates

Abstract

The title compounds 4 have been obtained in high yields in a one-step sequence by the Mitsunobu reaction of diethyl 1-hydroxyalkylphosphonates 1 with hydrazoic acid, and subsequence treatment of the inter-mediate azides 2 with triphenylphosphine, followed by hydrolysis of the iminophosphoranes 3 with water.