Bisphosphonic Compounds. II. Preparation of Monophosphonic Starting Materials. Mixed Esters of Methylphosphonic Acid

Vepsäläinen Jouko Univ. Kuopio, Dept. Chem., P.O. Box 1627, SF-70211, Kuopio, Finland

Nupponen Heikki Huhtamaki Oy Leiras, P.O. Box 33 SF-33721, Tampere, Finland

Pohjala Esko Huhtamaki Oy Leiras, P.O. Box 33 SF-33721, Tampere, Finland

Abstract

Methyl (1-methylelhyl) methylphosphonate was obtained from PCI₃ via (PrⁱO)PCI₂ and (PrⁱO)P(OMe)₂ followed by the Michaelis-Arbuzov reaction with Mel. The yield was 79% with 95% chemical purity. Less reasonable conversions were obtained for some related mixed diesters.

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Bisphosphonic Compounds. II. Preparation of Monophosphonic Starting Materials. Mixed Esters of Methylphosphonic Acid

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Bisphosphonic Compounds. II. Preparation of Monophosphonic Starting Materials. Mixed Esters of Methylphosphonic Acid

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