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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 24, 1994 - Issue 6
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Original Articles

A Simple Preparation of Chloromethyl Esters of the Blocked Amino Acids

Naoyuki Harada Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd., 2-2-50 Kawagishi, Toda, Saitama, 335, Japan
,
Mitsuya Hongu Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd., 2-2-50 Kawagishi, Toda, Saitama, 335, Japan
,
Takashi Tanaka Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd., 2-2-50 Kawagishi, Toda, Saitama, 335, Japan
,
Takayuki Kawaguchi Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd., 2-2-50 Kawagishi, Toda, Saitama, 335, Japan
,
Tomiki Hashiyama Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd., 2-2-50 Kawagishi, Toda, Saitama, 335, Japan
&
Kenji Tsujihara Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd., 2-2-50 Kawagishi, Toda, Saitama, 335, Japan
Pages 767-772 | Received 18 Aug 1993, Published online: 16 Feb 2007
 
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Abstract

An efficient synthesis of various chloromethyl esters of the blocked amino acids, very useful reagents for prodrug, are described.

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