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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 25, 1995 - Issue 6
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Original Articles

Synthesis of 3-Amino 3-Phenyl Azetidine

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Pages 803-812 | Received 12 Sep 1994, Published online: 23 Sep 2006
 

Abstract

We report a convenient preparation of 3-amino 3-phenyl azetidine from N-benzhydryl 3-azetidinone. Our strategy involves a modified Strecker reaction using dibenzylamine as an amino equivalent followed by the displacement of the cyano group by phenyl magnesium bromide and a final catalytic hydrogenation.

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