The Nickel and Palladium Catalysed Stereoselective Cross Coupling of Cyclopropyl Nucleophiles with Aryl Halides

Abstract

The reaction of 2-phenylcyclopropylzinc chloride with some substituted (het)aryl halides gave the corresponding coupling products with good yields and stereoselectivities under the influence of a catalytic amount of Pd(PPh₃)₄. Other Ni-and Pd-catalysts were less efficient. Alkyl-substituted cyclopropyl nucleophiles gave lower yields.