Dinitrogen Tetroxide Copper Nitrate Complex [Cu(NO₃)₂.N₂O₄] As a New Nitrosating Agent for Catalytic Coupling of Thiols via Thionitrite

Abstract

A catalytic and efficient oxidative coupling of thiols to disulfides is described using Cu(NO₃)₂.N₂O₄ as a new and efficient nitrosating agent in acetone at room temperature. The reaction is shown to occur immediately through the intermediacy of a thionitrite.

Notes

The reaction was performed between 1,3 propanedithiol (2 mmol) and Cu(NO₃)₂, N₂O₄ (0.4 mmol) in acetone (200 ml) at room temperature. After 8 h, the product was isolated according to the procedure and identified by its ¹H, ¹³C-NMR and mass spectra data.