Physicochemical and blood compatibility characteristics of garlic incorporated polyurethane nanofibrous scaffold for wound dressing applications

Abstract

Novel nanocomposite membrane based on polyurethane incorporated with garlic was fabricated using electrospinning technique for wound healing applications. Morphological analysis indicated that the incorporation of garlic into the polyurethane (PU) matrix resulted in reduction of fiber diameter and pore size compared to the pristine PU. Infrared analysis revealed the possible interaction of garlic with the PU through hydrogen bond formation. The contact angle studies and roughness measurements revealed the improved wettability and increased surface roughness of the fabricated composite compared to the pristine PU. The blood compatibility assay revealed the faster blood clotting time for the fabricated nanocomposites than the pristine PU. Furthermore, the fabricated nanocomposites showed less hemolytic index compared to the pristine PU suggesting their safety to red blood cells. Hence, with those advanced qualities PU blended with grapes may serve as a valuable candidate for wound dressing applications.

Keywords:

• Polyurethane
• garlic
• physico-chemical characterization
• biocompatibility
• wound dressing applications

Disclosure statement

No potential conflict of interest was reported by the authors..

Additional information

Funding

This work was partly supported by the Ministry of Higher Education Malaysia with the Grant no. Q. J130000.2545.17H00 and Q. J130000.2545.20H00.