ABSTRACT
A combination of drug profiling analysis, statistical filtering of selected data, database prioritization and comparative evaluation of potentially linked impurity profiles is utilized in order to positively confirm a set of chemical links from a large amount of data whilst maintaining the greatest significance to our stakeholders.
Acknowledgements
We would like to acknowledge Kaye Ballantyne for construction of the Excel interface with SPSS, Catherine Quinn, Joanne Gerstner-Stevens, Ben Archer and Jim Pearson for proof-reading of the manuscript. The method for sample preparation/analysis of samples by impurity profiling has been adapted from a method originally supplied by the National Measurement Institute (NMI).
Disclosure statement
No potential conflict of interest was reported by the authors.