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Summary
Urine samples were collected from two groups of pigs during a 10-week period of exposure to a natural infection of Leptospira interrogans serotype pomona. One group was protected against infection by immunization.
No differences were observed between the degree of proteinuria in infected and protected, animals. However, urine from infected pigs was more dilute than that from protected pigs. This was reflected in the paler colour, lower refractive index and lower untraviolet absorbance of urine samples from infected pigs. Sodium and potassium ion concentrations correlated with the degree of dilution and did not show any increase as a result of infection.
These findings suggest that infection of pigs with pomona does not lead to severe functional kidney damage.