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Abstract
The hardjo component of a bivalent pomona/hardjo vaccine was evaluated, using sheep. Nine sheep were vaccinated and 10 remained unvaccinated. All sheep were challenged with an intraperitoneal and intramuscular injection of a hardjo culture. After 13 weeks, the sheep were slaughtered and their kidneys cultured for leptospires.
There was a highly significant difference between the culture results from the two groups (p<0.001); 10/10 (100%) of the unvaccinated animals gave positive cultures compared with 2/9 (22%)of the vaccinates.
