262
Views
23
CrossRef citations to date
0
Altmetric
Scientific Article

Oestradiol and genistein reduce food intake in male and female overweight cats after gonadectomy

, , &
Pages 113-119 | Received 31 Jul 2006, Accepted 26 Feb 2007, Published online: 18 Feb 2011
 

Abstract

AIM: To determine if exogenous oestradiol or the phyto-oestrogen genistein could reduce food intake in male and female cats fed ad libitum that had been allowed to accrue excessive bodyfat following neutering.

METHODS: Sixteen adult (eight female, eight male) cats were neutered and allowed to increase their bodyweight (BW) through feeding ad libitum of a complete and balanced dry diet. Oestradiol was injected subcutaneously for 5-day periods in incremental doses (0.25–4 µg per cat), then food intake was recorded, and vaginal cytological changes were observed in females. Similarly, genistein was administered orally for 5-day periods in incremental doses (5–100 mg/kg).

RESULTS: In males and females, both oestradiol (p<0.001) and genistein (p=0.037) significantly reduced food intake during treatment, and the minimum daily doses that produced a significant effect were 0.5 µg and 100 mg/kg, respectively. The minimum daily dose of oestradiol that produced a significant effect on food intake was not associated with changes in vaginal cytology over the 5-day treatment period.

CONCLUSIONS AND CLINICAL RELEVANCE: Gonadal oestradiol appeared to be a key modulator of food intake in both male and female cats, and replacement of oestrogen to neutered cats via oestradiol or an oestrogen surrogate such as genistein has potential for reducing the prevalence of obesity in neutered cats.

Acknowledgements

The authors gratefully acknowledge provision of funding for the research through a fellowship awarded to Dr NJ Cave by the Center for Companion Animal Heath, School of Veterinary Medicine, University of California, Davis. The authors thank Ms Debbie Bee and staff of the Feline Nutrition and Pet Care Center of the School of Veterinary Medicine for their roles in completing the research. Funding for this research was also partly received from the pet food industry.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 213.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.