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Xenobiotica
the fate of foreign compounds in biological systems
Volume 49, 2019 - Issue 1
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Animal Pharmacokinetics and Metabolism

Metabolic profiles of corydaline in rats by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry

Liwei ChaiSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China, ;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China,
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Paul Owusu DonkorSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China, ;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China, ;School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana, and
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Kun WangSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China, ;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China,
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Yingjie SunSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China, ;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China,
,
Mahmood Brobbey OppongSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China, ;Department of Pharmaceutical Chemistry, School of Pharmacy, College of Health Sciences, University of Ghana, Legon, Ghana
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Kai WangSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China,
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Liqin DingTianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China, Correspondence[email protected]
&
Feng QiuSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China, ;Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, P.R. China, Correspondence[email protected]
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Pages 80-89 | Received 17 Oct 2017, Accepted 08 Dec 2017, Published online: 27 Dec 2017
 
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Abstract

1. Corydaline, an isoquinoline alkaloid obtained from the rhizomes of Corydalis yanhusuo, exhibits anti-acetylcholinesterase, anti-angiogenic, anti-allergic and gastric-emptying activities. In this study, a rapid and reliable ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) method was developed and employed for the comprehensive study of the metabolites of corydaline in rats.

2. Altogether, 43 metabolites were identified in the plasma (11), bile (9), urine (34) and feces (21) of rats after oral administration of corydaline at a dose of 4.5mg/kg.

3. It was demonstrated that demethylation, hydroxylation, sulfation and glucuronidation were the major metabolic transformation pathways. Among these, two metabolites were identified as tetrahydropalmatine and isocorybulbine, and 33 phase I and phase II products were inferred to be new metabolites arising from the in vivo metabolism of corydaline.

4. Importantly, this research provides scientific and reliable support for full understanding of the metabolic profiles of corydaline and the results could help to elucidate its safety and efficacy.

Supplementary material available online

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