Abstract
Challenges, strategies and new technologies in the field of biotransformation were presented and discussed at the 3rd European Biotransformation Workshop which was held in collaboration with the DMDG on 5–6 October 2022 in Amsterdam. In this meeting report we summarise the presentations and discussions from this workshop. The topics covered are listed below:
Accelerator mass spectrometry (AMS) for the support of microtracer studies
Biotransformation of the novel myeloperoxidase inhibitor AZD4831 in preclinical species and humans
AMS in biotransformation studies: unusual case studies
Discussion on new FDA draft guidance and AMS
Multimodal molecular imaging and ion mobility applications in drug discovery and development
Metabolites in Safety Testing considerations for large molecules
Acknowledgements
The organizers would like to extend their gratitude to all presenters (Stefan Blech, Bojan Bister, Ulrik Jurva, Axel Pähler, Georges Da Violante, Russell Mortishire-Smith, Christian Lanshoeft, Lloyd King, Markus Walles), and to all participants for fruitful discussions. We would like to acknowledge also the DMDG organizing and technical team, in particular Stuart Hex and Chris Barron (AssociAction Enterprises). Without their support, this event would have not been possible.
Disclosure statement
No potential conflict of interest was reported by the author(s).