Meeting report of the 4th European biotransformation workshop

Abstract

1. Challenges, strategies and new technologies in the field of biotransformation were presented and discussed at the fourth European Biotransformation Workshop which was held in collaboration with the joint ISSX/DMDG meeting on June 15, 2023 at the University of Hertfordshire in Hatfield, UK.

2. In this meeting report we summarise the presentations and discussions from this workshop.

3. The topics covered are listed below:

• Unusual biotransformation reactions

• Biotransformation Workflows in Discovery utilising various softwares for structure elucidation

• Biotransformation software for the identification of peptide metabolites

• Accelerator Mass Spectrometry (AMS) for endogenous and xenobiotic metabolite profiling

• Metabolite profiling using quantitative Nuclear magnetic resonance (NMR) and liquid chromatography coupled to inductively coupled plasma-mass spectrometry (LC-ICP-MS)

Keywords:

• Unusual biotransformation reactions
• Mass-MetaSite
• biotransformation softwares
• AMS
• F-NMR for metabolite profiling
• LC-ICP-MS for metabolite profiling

Acknowledgements

The organizers would like to extend their gratitude to all presenters (Emre Isin, Axel Pähler, Dan Weston, Ismael Zamora, Elwin Verheij, Alexander David James and Petra Kern) and to all participants for fruitful discussions. We would like to acknowledge also the ISSX/DMDG organizing and technical team, in particular Stuart Hex and Chris Barron (AssociAction Enterprises). Without their support, this event would have not been possible.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.