Synthesis and Properties of Temperature-Sensitive Hydrogel Based on Hydroxyethyl Cellulose

Abstract

Hydrogels were prepared from modified hydroxyethyl cellulose by copolymerization with N-isopropylacrylamide. The equilibrium swelling ratio of hydrogel was measured in buffer solution with pH 7.0 from 25.0 to 45.0°C and the data obtained showed that hydrogels exhibited temperature sensitivity. The results of DSC analysis revealed that the low critical solution temperature (LCST) of hydrogels was enhanced by the introduction of hydroxyethyl cellulose. SEM images suggested that the cross-section of freeze-dried hydrogels was porous. The data of adsorption and release experiments for two model drugs suggest that the controlled drug release can be achieved.

Keywords:

• 2,4-toluene diisocyanate
• hydrogel
• hydroxyethyl cellulose
• monoblock
• N-isopropylacrylamide
• temperature-sensitive

This project is supported by Hi-Tech Research and Development Program of China (Contract Grant Number: 2007AA100704).