In-Vitro Release Study of Metoprolol Succinate from the Bioadhesive Films of Pullulan-Polyacrylamide Blends

Abstract

In the present work, an attempt has been made to investigate the drug release profile of pullulan-polyacrylamide blend films with metoprolol succinate as a model drug. The drug diffusion behavior of pullulan/polyacrylamide films has been established by an open glass diffusion cell at 37 ± 1°C. The diffusion rate of the drug was determined by UV/visible spectroscopy. The kinetics of drug release are fitted to the Higuchi and Koresmeyer–Peppas model. The drug release kinetics for the blend was found to be fast and follows Fickian mechanism. This blend could be a promising approach for formulating a transdermal drug delivery system for immediate release with good film-forming property.

Keywords:

• drug release
• FTIR
• hydrophilic
• in vitro
• polymer

Acknowledgments

The authors express their gratitude to BARC, Mumbai, for financial support under BRNS project No. 2009/34/19/BRNS, and also gratefully acknowledge Dr. Kurunji Venkataramana Gowda, Founder President, AOLE, Sullia, and Dr. N. A. Jnanesh, Principal, KVG College of Engineering, Sullia, for providing infrastructure facilities.

Notes

*Standard deviation, n = 3.