Biological Assessment of Composite Materials Based on Poly-L-lactide and Bovine Bone

Abstract

Biodegradable polymers and bioactive fillers are being combined in a variety of composite materials for biomedical application. Biological properties in vivo of poly-L-lactide (PLLA) matrix containing bovine bone were investigated by using acute systemic toxicity in vivo, blood biocompatibility, sensitivity, pyrogen, and genetic toxicity testing methods. The results indicated that there were no toxic and death cases observed in the acute systemic toxicity test. The PLLA/bovine bone composite showed no genetic toxicity, pyrogen, or sensitizing response and the hemolytic index was 0.29%. The results from these studies demonstrated that PLLA/bovine bone has a good biocompatibility and good biological safety. Therefore, PLLA/bovine bone composite materials can be promising biomedical materials for bone tissue engineering.

Keywords:

• Biological properties
• bovine bone
• composite
• poly-L-lactide

Acknowledgment

This work was financially supported by the National Natural Science Fund of China (No. 51273062), the Hunan Provincial Natural Science Fund of China (No. 12JJA003), the Scientific Research Fund of Hunan Provincial Education Department (No. 11B045), and the Planning Science and Technology Project of Hunan Province, P. R. China (No. 2010SK3060).